Yoarly, Your Early Warning, by MDY Analytics
Biomarkers

Every biomarker, reported continuously

A surrogate for every biomarker, organised by organ system, so that the values which define clinical events are always in view.

Surrogate biomarkers

Every biomarker, continuously, without a sample

A test gives a biomarker at one moment. Between tests the value moves unseen. A Yoarly surrogate reports the same biomarker at every moment, so a change is seen as it happens and its course can be forecast.

Intermittent testing unseen Yoarly surrogate rise seen as it happens TIME
Figure 2Illustration. The same biomarker read at intervals and read continuously. The continuous reading shows the change between tests.

Perfusion and gas exchange

  • Lactate
  • pH
  • Bicarbonate
  • PaCO2
  • PaO2/FiO2
  • SaO2

Renal and electrolytes

  • Creatinine
  • eGFR
  • Potassium
  • Calcium

Liver

  • Bilirubin
  • ALT
  • AST

Coagulation

  • Platelets
  • INR
  • D-dimer
  • Fibrinogen

Infection and host response

  • C-reactive protein
  • Procalcitonin
  • Neutrophil count

Cardiac

  • Troponin
  • NT-proBNP

Glycaemic and metabolic

  • Glucose
  • HbA1c
  • Osmolality

Every biomarker

The programme is organised by organ system and continues until every biomarker has its surrogate.

Conditions and biomarkers

Each condition is defined by its biomarkers

Clinical conditions are recognised and staged by biomarkers. To warn of a condition, Yoarly must hold the biomarkers that define it. This is why the surrogate programme extends to every biomarker: each one completed brings further conditions within reach of the warning.

LactatepHBicarbonatePaCO2PaO2/FiO2CreatininePotassiumBilirubinALTASTPlateletsINRD-dimerFibrinogenC-reactive proteinProcalcitoninNeutrophilsTroponinNT-proBNPGlucoseOsmolalitySeptic shockSepsis with organ dysfunctionNeutropenic sepsisRespiratory failureAcute kidney injuryAcute liver injuryCoagulopathyMyocardial infarctionHeart failureDiabetic ketoacidosisHyperosmolar hyperglycaemic state
Figure 3Conditions and the biomarkers that define or stage them. Each mark is a biomarker Yoarly reports continuously in order to warn of the condition on that row.